Asian Nursing Research
Volume 3, Issue 1 , Pages 31-40, March 2009

BMI and Breast Cancer in Korean Women: A Meta-Analysis

  • Dukyoo Jung

      Affiliations

    • Division of Nursing Science, College of Health Sciences, Ewha Womans University, Seoul, Korea
    • ,
  • Sun-Mi Lee

      Affiliations

    • College of Nursing, The Catholic University of Korea, Seoul, Korea
    • Corresponding Author InformationCorrespondence to: Sun-Mi Lee, College of Nursing, The Catholic University of Korea, Banpo-dong, Seochu-gu, Seoul, Korea 137-701

Received 21 January 2009; received in revised form 30 January 2009; accepted 3 March 2009.

Article Outline

Introduction

The number of breast cancer women has increased dramatically in Korea. The cause is perceived to stem from adaptation to a westernized life style which increases body mass index (BMI). However, there are no meta-analysis data available that could help in understanding the relationship between Korean females' BMI and breast cancer occurrence.

Method

All the published articles that investigated the relationship of Korean women's BMI with breast cancer prevalence between 1950 and 2007 were included in this study, based on a screen of the comput- erized databases that search for these articles (MEDLINE, RISS4U and KMBase). The commercial software Comprehensive Meta Analysis was used for the analysis.

Results

The high BMI score group presented a higher prevalence of breast cancer on both a fixed-effects model [odds ratio (OR) = 1.282; 95% confidence interval (CI) = 1.209, 1.361] and a random-effects model (OR = 1.388; 95% CI = 1.129, 1.706). In addition, a high BMI score on pre- and postmenopausal groups was found to have a significantly higher prevalence of breast cancer on both a fixed-effects model (OR = 1.467; 95% CI = 1.268, 1.698, OR = 1.614; 95% CI = 1.360, 1.917, pre- and postmenopausal, respectively) and a random-effects model (OR = 1.387; 95% CI = 1.134, 1.696, OR = 1.681; 95% CI = 1.149, 2.461, pre- and postmenopausal, respectively).

Conclusion

This meta-analysis of Korean women showed that a high BMI was related to a higher inci- dence rate of breast cancer. This study used a subgroup analysis of pre- and postmenopausal groups; the high BMI subset in both the pre- and postmenopausal groups was shown to have a higher incidence rate of breast cancer. [Asian Nursing Research 2009;3(1):31–40]

Key Words:  body mass index , breast cancer , Korean women , meta-analysis , systematic review

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References 

  1. Axelrod D , Smith J , Kornreich D , Grinstead E , Singh B , Cangiarella J . Breast cancer in young women . Journal of American College Surgeons . 2008;206:1193–1203
  2. Bissonauth V , Shatenstein B , Ghadirian P . Nutrition and breast cancer among sporadic cases and gene mutation carriers: An overview . Cancer Detection and Prevention . 2008;32:52–64
  3. Carpenter CL , Ross RK , Paganini-Hill A , Bernstein L . Effect of family history, obesity and exercise on breast cancer risk among postmenopausal women . International Journal of Cancer . 2003;106:96–102
  4. Clark GM , McGuire WL , Hubay CA , Peterson OH , Marshall JS . Progesterone receptors as a prognostic factor in stage II breast Cancer . The New England Journal of Medicine . 1983;309:1343–1347
  5. Connolly BS , Barnett C , Bogt KN , Li T , Sone J , Boyd NF . A meta-analysis of published literature on waist-to-hip ratio and risk of breast cancer . Nutritional and Cancer . 2002;44:127–138
  6. DerSimonian R , Laird N . Meta-analysis in clinical trials . Controlled Clinical Trials . 1986;7:177–188
  7. Endogenous Hormones and Breast Cancer Collaborative Group  . Body mass index, serum sex hormones, and breast cancer risk in post menopausal women . Journal of the National Cancer Institute . 2003;95:1218–1226
  8. Gloecker-Reis L , Pollack ES , Young JL . Cancer patient survival . Journal of the National Cancer Institute . 1983;70:693–707
  9. Harvie M , Hooper L , Howell AH . Central obesity and breast cancer risk: A systematic review . Obesity Reviews . 2003;4:157–173
  10. Hede K . Fat may fuel breast cancer growth . Journal of the National Cancer Institute . 2008;100:298–299
  11. Hjartaker A , Langseth H , Weiderpass E . Obesity and diabetes epidemics: Cancer repercussions . Advances in Experimental Medicine and Biology . 2008;630:72–93
  12. Jakicic JM , Otto AD . Treatment and prevention of obesity: What is the role of exercise? . Nutrition Reviews . 2006;64:57–61
  13. Korean National Statistical Office  . The cause of death statistics, 2002 . Seoul, Korea: Author; 2003;
  14. Lee SM , Park JH , Park HJ . Breast cancer risk factors in Korean women: A literature review . International Nursing Review . 2008;55:355–359
  15. Lee SR . A case-control study on related factors of breast cancer in Korean women . Journal of Public Health and Social Science . 2001;10:97–115
  16. Lim, S. M. (2005). BMI and breast cancer risk Korean medical insurance corporation study. Unpublished master's thesis, Yonsei Univesity, Seoul, Korea.
  17. Manni A . Hormone receptors and breast cancer . The New England Journal of Medicine . 1983;309:1383–1385
  18. Maruti SS , Willett WC , Feskanich D , Rosner B , Colditz GA . A prospective study of age-specific physical activity and premenopausal breast cancer . Journal of the National Cancer Institute . 2008;100:728–737
  19. Muller CB , Ames F , Anderson GD . Breast cancer in 3558 women: Age as a significant determinant in the rate of dying and causes of death . Surgery . 1978;83:123–132
  20. National Cancer Center  . Annual report of the central cancer registry in Korea . Seoul, Korea: Author; 2002;
  21. Song YM , Sung J , Ha M . Obesity and risk of cancer in postmenopausal Korean women . Journal of Clinical Oncology . 2008;26:3395–3402
  22. Stroup DF , Berlin JA , Morton SC , Olkin I , Williamson GD , Rennie D . Meta-analysis of observational studies in epidemiology . Journal of the American Medical Association . 2000;283:2008–2012
  23. Sweeney C , Blair CK , Anderson KE , Lazovich D , Folsom AR . Risk factors for breast cancer in elderly women . American Journal of Epidemiology . 2004;160:868–875
  24. Ursin G , Longnecker MP , Haile RW , Greenland S . A meta-analysis of body mass index and risk of premenopausal breast cancer . Epidemiology . 1995;6:137–141
  25. WHO  . BMI classification . Retrieved October 8, 2008., from http://www.who.int/bmi/index.jsp?introPage = intro_3.html
  26. Yoo KY . Epidemiology and risk factors of breast cancer . Journal of Korean Medical Association . 2003;46:482–489
  27. Yoo KY , Kang D , Park SK , Kim SU , Shin A , Yoon H . Epidemiology of breast cancer in Korea: Occurrence, high-risk groups, and prevention . Journal of Korean Medical Science . 2002;17:1–6

PII: S1976-1317(09)60014-1

doi:10.1016/S1976-1317(09)60014-1

Asian Nursing Research
Volume 3, Issue 1 , Pages 31-40, March 2009

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